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Select item 75000331.

Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland

Genome Biol. 2020; 21: 248. Published online 2020 Sep 17. doi: 10.1186/s13059-020-02138-5

PMCID:: PMC7500033

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RanDeL-Seq: a High-Throughput Method to Map Viral cis- and trans-Acting Elements

Timothy Notton, Joshua J. Glazier, Victoria R. Saykally, Cassandra E. Thompson, Leor S. Weinberger

mBio. 2021 Jan-Feb; 12(1): e01724-20. Published online 2021 Jan 19. doi: 10.1128/mBio.01724-20

PMCID:: PMC7845639

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Select item 59828333.

A Cloning-Free Method for CRISPR/Cas9-Mediated Genome Editing in Fission Yeast

Xiao-Ran Zhang, Jia-Bei He, Yi-Zheng Wang, Li-Lin Du

G3 (Bethesda) 2018 Jun; 8(6): 2067–2077. Published online 2018 Apr 27. doi: 10.1534/g3.118.200164

PMCID:: PMC5982833

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Select item 71396724.

Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters

Ronny Martínez, Claudia Bernal, Rodrigo Álvarez, Christopher Concha, Fernando Araya, Ricardo Cabrera, Gaurao V. Dhoke, Mehdi D. Davari

Int J Mol Sci. 2020 Mar; 21(6): 1990. Published online 2020 Mar 14. doi: 10.3390/ijms21061990

PMCID:: PMC7139672

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Extensive libraries of gene truncation variants generated by in vitro transposition

Aleardo Morelli, Yari Cabezas, Lauren J. Mills, Burckhard Seelig

Nucleic Acids Res. 2017 Jun 2; 45(10): e78. Published online 2017 Jan 27. doi: 10.1093/nar/gkx030

PMCID:: PMC5449547

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Application of counter-selectable marker PIGA in engineering designer deletion cell lines and characterization of CRISPR deletion efficiency

Donghui Li, Xiaoji Sun, Fangzhou Yu, Mary Ann Perle, David Araten, Jef D Boeke

Nucleic Acids Res. 2021 Mar 18; 49(5): 2642–2654. Published online 2021 Feb 16. doi: 10.1093/nar/gkab035

PMCID:: PMC7969003

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Effect of the Southeast Asian Ovalocytosis Deletion on the Conformational Dynamics of Signal-Anchor Transmembrane Segment 1 of Red Cell Anion Exchanger 1 (AE1, Band 3, or SLC4A1)

Philip W. Fowler, Mark S. P. Sansom, Reinhart A. F. Reithmeier

Biochemistry. 2017 Feb 7; 56(5): 712–722. Published online 2017 Jan 9. doi: 10.1021/acs.biochem.6b00966

PMCID:: PMC5299548

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FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

Yichao Fan, Jiao Yue, Mengtao Xiao, Han Han-Zhang, Yao Vickie Wang, Chun Ma, Zhilin Deng, Yingxiang Li, Yanyan Yu, Xinghao Wang, Shen Niu, Youjia Hua, Zhiping Weng, Peter Atadja, En Li, Bin Xiang

eLife. 2017; 6: e26129. Published online 2017 Aug 2. doi: 10.7554/eLife.26129

PMCID:: PMC5595435

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Targeted large fragment deletion in plants using paired crRNAs with type I CRISPR system

Yingnan Li, Boyu Huang, Jian Chen, Liangliang Huang, Jianghai Xu, Yingying Wang, Guanghui Cui, Haiming Zhao, Beibei Xin, Weibin Song, Jian‐Kang Zhu, Jinsheng Lai

Plant Biotechnol J. 2023 Nov; 21(11): 2196–2208. Published online 2023 Aug 29. doi: 10.1111/pbi.14122

PMCID:: PMC10579709

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Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2

Cinthya J. Zepeda-Mendoza, Swagatam Mukhopadhyay, Emily S. Wong, Nathalie Harder, Erik Splinter, Elzo de Wit, Melanie A. Eckersley-Maslin, Thomas Ried, Roland Eils, Karl Rohr, Alea Mills, Wouter de Laat, Paul Flicek, Anirvan M. Sengupta, David L. Spector

BMC Genomics. 2015; 16: 982. Published online 2015 Nov 21. doi: 10.1186/s12864-015-2137-5

PMCID:: PMC4654810

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Select item 955313911.

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

Zhaobin Xu, Dongying Yang, Liyan Wang, Jacques Demongeot

Virulence. 2022; 13(1): 1772–1789. Published online 2022 Oct 10. doi: 10.1080/21505594.2022.2132059

PMCID:: PMC9553139

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Select item 682176012.

A large intragenic deletion in the CLCN1 gene causes Hereditary Myotonia in pigs

C. E. T. Araújo, C. M. C. Oliveira, J. D. Barbosa, J. P. Oliveira-Filho, L. A. L. Resende, P. R. Badial, J. P. Araujo-Junior, M. E. McCue, A. S. Borges

Sci Rep. 2019; 9: 15632. Published online 2019 Oct 30. doi: 10.1038/s41598-019-51286-7

Correction in:: Sci Rep. 2020; 10: 3732.

PMCID:: PMC6821760

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Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

Yaw Aniweh, Jonathan Suurbaar, Collins M. Morang’a, Prince B. Nyarko, Katherine E. Wright, Kwadwo A. Kusi, Felix Ansah, Eric Kyei-Baafour, Evelyn Quansah, Jessica Asante, Laty G. Thiam, Matthew K. Higgins, Gordon A. Awandare

Sci Rep. 2020; 10: 1498. Published online 2020 Jan 30. doi: 10.1038/s41598-020-58300-3

PMCID:: PMC6992740

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Select item 714565414.

Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins

Zachary J Romero, Thomas J Armstrong, Sarah S Henrikus, Stefanie H Chen, David J Glass, Alexander E Ferrazzoli, Elizabeth A Wood, Sindhu Chitteni-Pattu, Antoine M van Oijen, Susan T Lovett, Andrew Robinson, Michael M Cox

Nucleic Acids Res. 2020 Jan 10; 48(1): 212–230. Published online 2019 Oct 30. doi: 10.1093/nar/gkz960

PMCID:: PMC7145654

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Mechanisms of replication and repair in mitochondrial DNA deletion formation

Gabriele A Fontana, Hailey L Gahlon

Nucleic Acids Res. 2020 Nov 18; 48(20): 11244–11258. Published online 2020 Oct 6. doi: 10.1093/nar/gkaa804

PMCID:: PMC7672454

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Select item 584432916.

Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice

Kenneth R. Johnson, Leona H. Gagnon, Cong Tian, Chantal M. Longo-Guess, Benjamin E. Low, Michael V. Wiles, Amy E. Kiernan

Genetics. 2018 Mar; 208(3): 1165–1179. Published online 2018 Jan 3. doi: 10.1534/genetics.117.300447

PMCID:: PMC5844329

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Select item 848326117.

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in cancer patients

Emre Kocakavuk, Kevin J. Anderson, Frederick S. Varn, Kevin C. Johnson, Samirkumar B. Amin, Erik. P. Sulman, Martijn P. Lolkema, Floris P. Barthel, Roel G.W. Verhaak

Nat Genet. Author manuscript; available in PMC 2021 Nov 27.

Published in final edited form as: Nat Genet. 2021 Jul; 53(7): 1088–1096. Published online 2021 May 27. doi: 10.1038/s41588-021-00874-3

PMCID:: PMC8483261

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Select item 851898718.

Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines

David Brandt, Marina Simunovic, Tobias Busche, Markus Haak, Peter Belmann, Sebastian Jünemann, Tizian Schulz, Levin Joe Klages, Svenja Vinke, Michael Beckstette, Ehmke Pohl, Christiane Scherer, Alexander Sczyrba, Jörn Kalinowski

Viruses. 2021 Sep; 13(9): 1870. Published online 2021 Sep 18. doi: 10.3390/v13091870

PMCID:: PMC8518987

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Select item 924183219.

Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13

Tetsuya Akaishi

Microbiol Spectr. 2022 May-Jun; 10(3): e00716-22. Published online 2022 Jun 6. doi: 10.1128/spectrum.00716-22

PMCID:: PMC9241832

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Select item 593571220.

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

Kenichi Nagata, Mika Takahashi, Yukio Matsuba, Fumi Okuyama-Uchimura, Kaori Sato, Shoko Hashimoto, Takashi Saito, Takaomi C. Saido

Nat Commun. 2018; 9: 1800. Published online 2018 May 4. doi: 10.1038/s41467-018-04238-0

PMCID:: PMC5935712

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PMC Images search for terminal deletion【生化】

Figure 1

Different genetic rearrangements present in PMS, established by different cytogenetic/molecular techniques: (a) interstitial deletion by MLPA; (b) terminal deletion by microarray CGH; (c) terminal deletion and ring chromosome by FISH; (d) terminal deletion and ring chromosome by karyotype (GTL bands), (e) unbalanced translocation by karyotype, (f) terminal deletion by karyotype, (g) terminal deletion and other adjacent SNP-array rearrangements.

Clinical and Genetic Aspects of Phelan–McDermid Syndrome: An Interdisciplinary Approach to Management

Genes (Basel). 2022 Mar;13(3):504.
Figure 2

Molecular details of 2p25.3 deletion.Array- CGH profile of chromosome 2 showing (A) a terminal deletion of 1.9 Mb at 2p25.3, and (B) an enlargement of the 2p25.3 deletion. Genomic view of the terminal 1.9 Mb of chromosome 2p25.3(C): UCSC genes (GRCh37/hg19) are shown. The screenshot shows the deletion breakpoint disrupting MYT1L.

A new patient with a terminal de novo 2p25.3 deletion of 1.9 Mb associated with early-onset of obesity, intellectual disabilities and hyperkinetic disorder

Mol Cytogenet. 2014;7:53-53.
Figure 3

Enlargement of chromosome 4 with ideogram showing terminal deletion of band q31.2 – q35.2

Terminal 4q Deletion Syndrome

Indian J Dermatol. 2012 May-Jun;57(3):222-224.
Fig. 4

— Terminal deletion of the long arm of chromosome 1

Prenatal diagnosis of a terminal chromosome 1 (q42-q44) deletion: original case report and review of the literature

Facts Views Vis Obgyn. 2016 Jun 27;8(2):101-103.